Endocrine Abstracts

Purpose: Exposure to ionizing radiation in childhood has been recognized as a risk factor for the development of thyroid cancer and possibly for other thyroid disorders. However, the effects of neonatal radiation exposure on thyroid functions have never been explored experimentally despite its potential importance. We have demonstrated that neonatal rat thyroid was sensitive to ionizing radiation, developing specific morphological changes characterized by smaller thyroid folli...

It is not surprising that mouse prostate gland is anatomically very similar to that in the rat, which consists of the ventral prostate (VP), dorsolateral prostate (DLP) and anterior prostate (AP). However, the basic biological function of the prostate, prostatic secretion, has been suggested to be diverse between the two species and yet poorly understood. We have identified major secreted proteins from separate prostate lobes of the mouse as well as the rat by mass spectrometr...

Introduction: Radiation exposure at young ages is a risk of thyroid cancer. Although early studies of the infants treated with X-rays already indicated an association, the risk became well-known by a rapid rise in childhood thyroid cancer cases after the Chernobyl nuclear plant accident. Human cases have been investigated extensively, but the underlying mechanisms have yet to be elucidated. Our previous investigation in rats found that neonatal X-irradiation induced long-term ...